Investigating how mitochondrial signals affect inflammation in Alzheimer's disease
Official title: NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation
Funded at University of California, San Diego · NIH-11095856 · Data updated 2026-11-12
This study is looking at how changes in mitochondrial DNA might trigger inflammation in Alzheimer's disease, and it's trying to find ways to reduce that inflammation to help patients feel better.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $600,599 |
| NIH project number | 5R37AI043477-28 |
| Project ID | NIH-11095856 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease, particularly those with genetic factors such as the APOE e4 allele.
✕Less likely to help
Patients with non-neurological conditions or those not at risk for Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of mitochondrial DNA in the activation of the NLRP3 inflammasome, which is linked to inflammation in Alzheimer's disease. The team has discovered that oxidized mitochondrial DNA can activate this inflammasome, and they are exploring how this process is regulated by various cellular signals. By studying the mechanisms involved, including the role of specific enzymes and cellular pathways, the research aims to uncover potential therapeutic targets for reducing inflammation in Alzheimer's patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and potentially slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in targeting inflammation pathways in Alzheimer's disease, suggesting that this approach may be effective.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Karin, Michael — University of California, San Diego
- Study coordinator: Karin, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.