Investigating how mitochondrial quality control affects heart health as we age
Neddylation and mitophagy in cardiac aging
This study is looking at how a process called mitophagy, which helps clean up damaged parts of our cells, can keep our hearts healthy as we age, and it's testing a promising substance that might boost this process to improve heart function in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11052479 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mitophagy, a process that helps clear damaged mitochondria, in maintaining heart health during aging. By using advanced imaging techniques, the researchers aim to identify agents that can enhance mitophagy and potentially rejuvenate mitochondrial function. One promising agent, MLN4924, has been found to activate mitophagy effectively, which may help combat age-related cardiac dysfunction. The study seeks to explore how improving mitochondrial quality can lead to better heart health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over the age of 21 who are experiencing age-related heart dysfunction or decline.
Not a fit: Patients with non-age-related cardiac issues or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and overall health in aging individuals.
How similar studies have performed: Previous studies have shown promising results in enhancing mitophagy as a strategy to improve health outcomes in aging, indicating that this approach has potential for success.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Sun, Nuo — Ohio State University
- Study coordinator: Sun, Nuo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.