Investigating how mitochondrial proteins function and their role in Batten Disease.
Structure and mechanism of the mitochondrial ATP synthase and Batten Disease gene product, Cln3p
This study is looking at how a specific protein related to Batten Disease works in our cells, which could help us understand the disease better and find new ways to treat it for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rosalind Franklin Univ of Medicine & Sci NIH-funded |
| Lab location | 1 site (North Chicago, United States) |
| Project ID | NIH-10671747 on NIH RePORTER |
What this research studies
This research focuses on understanding the structure and function of mitochondrial ATP synthase and its relationship to Batten Disease through the study of a related protein, Cln3p. By using advanced techniques to capture the enzyme in various states, researchers aim to reveal how these proteins operate at a molecular level. This could lead to insights into how disruptions in these proteins contribute to diseases, potentially guiding the development of new treatments. Patients may benefit from a better understanding of their conditions and the development of targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Batten Disease or related neurodegenerative conditions.
Not a fit: Patients with conditions unrelated to mitochondrial dysfunction or Batten Disease may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Batten Disease and other related disorders.
How similar studies have performed: Previous research has shown promise in understanding membrane proteins and their roles in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
North Chicago, United States
- Rosalind Franklin Univ of Medicine & Sci — North Chicago, United States (Active)
Researchers
- Principal investigator: Mueller, David Michael — Rosalind Franklin Univ of Medicine & Sci
- Study coordinator: Mueller, David Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.