Investigating how mitochondrial problems affect tau-related brain issues in Alzheimer's disease
Official title: The role of mitochondrial deficits in tauopathy-linked autophagy defects
Funded at Rutgers, the State Univ of N.j. · NIH-11137856 · Data updated 2026-11-12
This study is looking at how problems with tiny energy factories in our cells, called mitochondria, might lead to brain changes that affect memory and thinking in people with Alzheimer's, and it hopes to find new ways to help keep the brain healthy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $431,750 |
| NIH project number | 1R21AG089974-01A1 |
| Project ID | NIH-11137856 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those showing early signs of cognitive impairment related to tau pathology.
✕Less likely to help
Patients with other forms of dementia not linked to tau pathology may not benefit from this research.
What this research studies
This research focuses on understanding the role of mitochondrial deficits in the development of tau pathology, which is linked to cognitive decline in Alzheimer's disease. The study aims to explore how these mitochondrial issues contribute to autophagy defects, a critical process for cellular health. By examining the relationship between mitochondrial function and tau accumulation, researchers hope to identify potential therapeutic targets that could improve neuronal health and cognitive function in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent cognitive decline in Alzheimer's disease patients.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between mitochondrial function and tau pathology, indicating that this approach could yield valuable insights.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Cai, Qian — Rutgers, the State Univ of N.j.
- Study coordinator: Cai, Qian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.