Investigating how mitochondrial polyphosphate affects stress responses in mammals.
Official title: Mitochondrial inorganic polyphosphate in the mammalian stress response.
Funded at Rutgers the State Univ of Nj Camden · NIH-10890057 · Data updated 2026-11-12
This study is looking at how a substance called inorganic polyphosphate helps our cells deal with stress, especially in the tiny energy factories called mitochondria, and it could lead to new treatments for diseases related to mitochondrial problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers the State Univ of Nj Camden NIH-funded |
| Lab location | 1 site (Camden, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $391,353 |
| NIH project number | 5R35GM150799-02 |
| Project ID | NIH-10890057 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with degenerative neurologic disorders or other conditions associated with mitochondrial dysfunction.
✕Less likely to help
Patients with non-mitochondrial related disorders or those without any cellular stress-related conditions may not benefit from this research.
What this research studies
This research explores the role of inorganic polyphosphate (polyP) in the mitochondria, particularly how it influences cellular stress responses in mammals. By examining the mechanisms of mitochondrial dysfunction during stress, the study aims to uncover how polyP contributes to maintaining cellular energy balance and homeostasis. The approach includes detailed biochemical assays and cellular models to assess the impact of polyP on mitochondrial processes, such as calcium regulation and energy metabolism. The findings could lead to new therapeutic strategies for diseases linked to mitochondrial dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for conditions related to mitochondrial dysfunction, improving patient outcomes.
How similar studies have gone: Previous research has shown that targeting mitochondrial processes can lead to significant advancements in understanding and treating related diseases, indicating a promising avenue for this investigation.
Where this research is happening
-
Rutgers the State Univ of Nj Camden
Camden, United States Active
Researchers
- Principal investigator: Solesio Torregrosa, Maria de la Encarnacion — Rutgers the State Univ of Nj Camden
- Study coordinator: Solesio Torregrosa, Maria de la Encarnacion
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.