Investigating how mitochondrial microRNAs affect kidney repair
Official title: Role of mitochondrial microRNAs (mitomiRs) in endogenous renal repair
Funded at Mayo Clinic Rochester · NIH-10978232 · Data updated 2026-11-12
This study is looking at how tiny molecules in our cells, called mitomiRs, can help repair kidneys in people with a condition called renal artery stenosis, which is common in older adults, and it hopes to find new ways to improve kidney health and recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $457,391 |
| NIH project number | 5R01DK129240-03 |
| Project ID | NIH-10978232 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly patients diagnosed with renal artery stenosis who are experiencing kidney dysfunction.
✕Less likely to help
Patients with kidney conditions unrelated to renal artery stenosis or those without significant kidney damage may not benefit from this research.
What this research studies
This research focuses on understanding the role of mitochondrial microRNAs (mitomiRs) in the repair mechanisms of the kidneys, particularly in patients with renal artery stenosis (RAS). It examines how RAS, a condition common in older adults, disrupts the natural repair processes of kidney cells, specifically the scattered tubular-like cells (STCs). By studying the effects of mitomiRs on mitochondrial function and cellular repair, the research aims to uncover potential therapeutic targets that could enhance kidney recovery and function. Patients may be involved in this research to help identify how these cellular processes can be improved.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance kidney repair and function in patients suffering from renal artery stenosis.
How similar studies have gone: Previous research has shown promising results in understanding the role of microRNAs in cellular repair, suggesting that this approach could yield significant insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Eirin, Alfonso — Mayo Clinic Rochester
- Study coordinator: Eirin, Alfonso
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.