Investigating how mitochondrial metabolism affects health and aging
Cell autonomous and cell non-autonomous roles for mitochondrial proline catabolism in health and longevity
This study looks at how tiny parts of our cells called mitochondria, which help produce energy, affect our health and how we age, especially by focusing on a specific enzyme; it's aimed at understanding how changes in these mitochondria can lead to early aging and muscle problems, using a small worm as a model to learn more about keeping our cells healthy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10998235 on NIH RePORTER |
What this research studies
This research explores the roles of mitochondria, the energy-producing organelles in cells, in maintaining health and longevity. It focuses on how mitochondrial metabolism, particularly involving the enzyme ALDH, influences cellular processes like metabolism and apoptosis. Using the model organism C. elegans, the study examines how mutations in mitochondrial genes can lead to early aging and muscle dysfunction. The goal is to understand both the cell-intrinsic and extrinsic effects of mitochondrial health on overall well-being.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in aging and mitochondrial health, particularly those with a family history of mitochondrial disorders.
Not a fit: Patients with acute mitochondrial dysfunction or those who are not affected by aging-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthy aging and preventing age-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function and its implications for aging, indicating that this approach has potential for significant findings.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Ramos, Maria Carmen — University of Southern California
- Study coordinator: Ramos, Maria Carmen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.