Investigating how mitochondrial health affects blood pressure and cardiovascular risk in adults
Official title: Mitochondrial health, cardiovascular risk, and blood pressure targets in hypertensive adults
Funded at Northern California Institute/res/edu · NIH-10900588 · Data updated 2026-11-12
This study is looking at how the health of tiny energy factories in our cells, called mitochondria, affects blood pressure treatment in adults with high blood pressure, to help find the best ways to manage it for different people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $663,944 |
| NIH project number | 5R01HL151564-04 |
| Project ID | NIH-10900588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with hypertension who are undergoing or considering intensive blood pressure management.
✕Less likely to help
Patients who are not hypertensive or those with contraindications to antihypertensive therapy may not benefit from this research.
What this research studies
This research explores the relationship between mitochondrial health and blood pressure management in adults with hypertension. It aims to identify specific patient subgroups that may experience different outcomes from intensive blood pressure lowering, particularly focusing on the risks and benefits associated with antihypertensive therapy. By integrating traditional risk factors with innovative mitochondrial DNA measures, the study seeks to enhance our understanding of how mitochondrial function influences cardiovascular health and treatment responses. Patients participating in this research may undergo assessments of their mitochondrial health to better tailor blood pressure management strategies.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective blood pressure treatment strategies, reducing cardiovascular risks for hypertensive patients.
How similar studies have gone: Previous studies have shown promising results in linking mitochondrial health to cardiovascular outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Jotwani, Vasantha Kolavennu — Northern California Institute/res/edu
- Study coordinator: Jotwani, Vasantha Kolavennu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.