Investigating how mitochondrial genetics affect the risk of sudden cardiac arrest and resuscitation outcomes.
Official title: Human Mitochondrial Variation and Sudden Cardiac Arrest Risk and Resuscitation
Funded at Johns Hopkins University · NIH-11074680 · Data updated 2026-11-12
This study is looking at how changes in mitochondrial DNA might affect the risk of sudden cardiac arrest and how well people respond to resuscitation, with the goal of finding new ways to help improve survival rates and create personalized treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 12, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $644,730 |
| NIH project number | 5R01HL170579-02 |
| Project ID | NIH-11074680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of cardiac issues or those at risk for sudden cardiac arrest due to genetic factors.
✕Less likely to help
Patients without any cardiovascular risk factors or those who have already experienced a cardiac arrest may not benefit from this research.
What this research studies
This research focuses on understanding the role of mitochondrial DNA variations in sudden cardiac arrest (SCA) risk and the effectiveness of resuscitation efforts. By examining genetic factors related to mitochondria, the study aims to identify new risk factors and potential therapeutic targets that could improve survival rates after cardiac arrest. The approach includes analyzing mitochondrial DNA copy number and haplotypes to assess their impact on heart and brain health during emergencies. Patients may benefit from insights that could lead to personalized prevention strategies and treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and better outcomes for patients experiencing sudden cardiac arrest.
How similar studies have gone: Previous research has shown that mitochondrial factors can influence cardiac health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Arking, Dan E — Johns Hopkins University
- Study coordinator: Arking, Dan E
Related research
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This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.