Investigating how mitochondrial function affects brain injury in newborns
Mitochondrial proton leak and neonatal brain injury
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11092234
This study is looking at how problems with tiny parts of cells called mitochondria can affect brain injuries in newborns who don't get enough oxygen, and it hopes to find new ways to help protect their developing brains.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11092234 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how mitochondrial dysfunction contributes to brain injuries caused by hypoxia-ischemia in newborns. The study examines the differences in mitochondrial behavior between neonates and adults, particularly how certain proteins influence cell death during brain injury. By using neonatal animal models, the research aims to identify new therapeutic approaches that could protect the developing brain from injury. The methodology includes assessing the biophysical properties of mitochondrial membranes and testing pharmacological interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns or infants who have experienced hypoxia-ischemia or are at risk for brain injury.
Not a fit: Patients who are adults or those who have not experienced hypoxia-ischemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce brain injury and disability in newborns affected by hypoxia-ischemia.
How similar studies have performed: While there has been research on mitochondrial dysfunction in adults, this specific approach focusing on neonates is novel and has not been extensively tested.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TEN, VADIM S — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: TEN, VADIM S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury