Investigating how mitochondrial function affects asthma in obese patients
Mitochondrial Redox Perturbations in Obese Allergic Asthma
This study is looking at how certain molecules in our cells might affect asthma in people who are obese, with the goal of finding new treatments that can help those who struggle with asthma and obesity together.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-10455740 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mitochondrial reactive oxygen species (mROS) in the development of asthma among obese individuals. By examining airway epithelial cells from different patient groups, the study aims to identify how mROS signaling contributes to allergic responses in obesity. The researchers will also explore the potential of targeting mROS and related pathways to develop new treatments for obese allergic asthma. This approach may lead to innovative therapies that specifically address the unique challenges faced by this patient population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and have been diagnosed with allergic asthma.
Not a fit: Patients who are not obese or do not have asthma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with obesity-related asthma, improving their quality of life and asthma control.
How similar studies have performed: While the specific approach of targeting mROS in obese allergic asthma is novel, related research has shown promising results in understanding mitochondrial function in asthma and obesity.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Dixon, Anne E — University of Vermont & St Agric College
- Study coordinator: Dixon, Anne E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.