Investigating how mitochondrial function affects aging-related diseases and health.
Official title: Mitochondrial Function and Multiomics in Aging-related Disease: Identifying Novel Biomarkers and Causal Relationships
Funded at Johns Hopkins University · NIH-11169940 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called mitochondria might affect health as we get older, especially in relation to heart disease and feeling weak, by examining blood samples from a large group of people to find clues that could help us understand aging better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 15, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $662,365 |
| NIH project number | 5R01AG085753-02 |
| Project ID | NIH-11169940 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 50 and older who may be experiencing aging-related health issues.
✕Less likely to help
Patients with acute mitochondrial diseases or those under 50 years of age may not benefit from this research.
What this research studies
This research explores the role of mitochondria in aging-related diseases by analyzing mitochondrial DNA and its variations in a large population. By utilizing advanced techniques such as whole-genome sequencing and metabolomics, the study aims to identify biomarkers that link mitochondrial function to health outcomes like cardiovascular disease and frailty. Patients' blood samples will be analyzed to uncover potential causal relationships between mitochondrial health and aging. The goal is to enhance our understanding of how mitochondrial function impacts overall health as we age.
Why it matters
Potential benefit: If successful, this research could lead to the identification of novel biomarkers for aging-related diseases, improving early detection and treatment options for patients.
How similar studies have gone: Previous research has shown promising results in linking mitochondrial function to aging and related diseases, suggesting that this approach could yield significant insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Arking, Dan E — Johns Hopkins University
- Study coordinator: Arking, Dan E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.