Investigating how mitochondrial fission contributes to Alzheimer's disease after brain injury
The role of mitochondrial fission in neurodegeneration in the leading environmental cause of Alzheimer's disease
This study is looking at how a specific process in brain cells, called mitochondrial fission, might play a role in developing Alzheimer's disease after a head injury, and it hopes to find ways to protect the brain and improve outcomes for people who have experienced traumatic brain injuries.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10873247 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mitochondrial fission in the development of Alzheimer's disease following traumatic brain injury (TBI). It aims to characterize how TBI affects the regulation of a key protein involved in mitochondrial fission, known as Drp1, in various brain regions over time. By using a mouse model, the researchers will explore whether reducing excessive mitochondrial fission can protect against neurodegeneration and the accelerated onset of Alzheimer's disease. This approach could lead to new therapeutic strategies for patients affected by TBI and related cognitive impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are at risk of developing Alzheimer's disease or related dementias.
Not a fit: Patients who have not experienced a traumatic brain injury or do not have a risk of developing Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of Alzheimer's disease in individuals who have suffered a traumatic brain injury.
How similar studies have performed: Other research has indicated that targeting mitochondrial dysfunction may provide neuroprotective benefits in neurodegenerative diseases, suggesting potential success for this approach.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Sridharan, Preethy — Case Western Reserve University
- Study coordinator: Sridharan, Preethy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.