Investigating how mitochondrial energy affects cognitive decline in aging brains
Mitochondrial Energetics, Circuits and Cognitive Decline in the Aging Human Brain
This study is looking at how the tiny powerhouses in our cells, called mitochondria, might affect our thinking and memory as we get older, especially in relation to Alzheimer's and other types of dementia, and it’s for people who want to understand how their brain health is connected to these energy-producing structures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10423361 on NIH RePORTER |
What this research studies
This research explores the role of mitochondria, the energy-producing structures in cells, in cognitive functions as people age. It examines how mitochondrial dysfunction may contribute to Alzheimer's disease and other forms of dementia. By analyzing data from a large cohort of individuals, including those with genetically-inherited mitochondrial disorders, the study aims to uncover the relationship between mitochondrial health and cognitive decline. Patients may undergo neuroimaging and cognitive assessments to better understand these connections.
Who could benefit from this research
Good fit: Ideal candidates for participation are older adults, particularly those showing early signs of cognitive decline or with a family history of Alzheimer's disease.
Not a fit: Patients who are not elderly or do not have cognitive decline or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the link between mitochondrial function and cognitive health, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Picard, Martin — Columbia University Health Sciences
- Study coordinator: Picard, Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.