Investigating how mitochondrial dysfunction contributes to vision loss in glaucoma
The role of impaired mitophagy and mitochondrial dysfunction in glaucomatous neurodegeneration
This study is looking at how high eye pressure affects the health of cells in the eye for people with glaucoma, using special mouse models to find new ways to protect vision and possibly improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11082659 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind primary open angle glaucoma (POAG), a condition that leads to irreversible vision loss due to the degeneration of retinal ganglion cells. The study utilizes innovative mouse models that mimic human glaucoma to explore how elevated intraocular pressure affects mitochondrial health and contributes to neurodegeneration. By examining the role of impaired mitophagy, the research aims to identify potential therapeutic strategies that could enhance mitochondrial function and prevent cell loss. Patients may benefit from insights that could lead to new treatments for glaucoma.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with primary open angle glaucoma who are experiencing vision loss.
Not a fit: Patients with other forms of glaucoma or those without any retinal degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that prevent vision loss in patients with glaucoma.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction in neurodegenerative diseases, suggesting potential for success in this area as well.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Maddineni, Prabhavathi — University of Missouri-Columbia
- Study coordinator: Maddineni, Prabhavathi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.