Investigating how mitochondrial dysfunction contributes to vision loss in aging
The Aging Eyes Study: mitochondrial dysfunction as a driver of age-related vision loss
This study is looking at how problems with tiny energy factories in our cells, called mitochondria, might be linked to vision loss as we get older, and it hopes to find ways to better spot and help those who are at risk of losing their sight.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10951166 on NIH RePORTER |
What this research studies
This research explores the connection between mitochondrial dysfunction and age-related vision loss, focusing on how oxidative stress and systemic inflammation may accelerate this process. By examining the role of mitochondria in energy production and cellular health, the study aims to identify indicators that can distinguish between normal age-related changes and more severe vision deterioration. The findings could lead to improved screening methods and targeted interventions for those at higher risk of vision loss as they age.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing changes in their vision.
Not a fit: Patients under the age of 65 or those without any vision changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better screening and treatment options for age-related vision loss, improving quality of life for older adults.
How similar studies have performed: Previous research has indicated that mitochondrial function plays a significant role in age-related diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Abraham, Alison G — University of Colorado Denver
- Study coordinator: Abraham, Alison G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.