Investigating how mitochondrial dysfunction contributes to diseases related to aging
The role of mitochondrial dysfunction in age-related disease: a human genetic approach
This study is looking at how problems with tiny parts of our cells called mitochondria might be linked to diseases that often come with aging, like Alzheimer's, heart disease, and diabetes, to help find new ways to prevent or treat these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10995334 on NIH RePORTER |
What this research studies
This research explores the connection between mitochondrial dysfunction and age-related diseases such as neurodegenerative disorders, coronary artery disease, and type 2 diabetes. By examining human genetic variations, the study aims to identify the mechanisms that lead to mitochondrial dysfunction and its role in the development of these chronic conditions. The research employs both novel and established methods to assess the relationship between mitochondrial health and aging, with the goal of determining causation. Patients may benefit from insights that could lead to new prevention or treatment strategies for age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who may be experiencing age-related chronic diseases.
Not a fit: Patients with acute conditions unrelated to aging or mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new understanding and potential treatments for chronic diseases associated with aging.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction in relation to aging, but this study aims to rigorously assess causation, making it a novel approach.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Gupta, Rahul — Harvard Medical School
- Study coordinator: Gupta, Rahul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.