Investigating how mitochondrial dysfunction affects tau pathology in Alzheimer's disease
Mitochondrial dysfunction and tau pathology in Alzheimer's disease
This study is looking at how problems with tiny energy factories in our cells, called mitochondria, might be linked to the brain changes seen in Alzheimer's disease, and it uses special light technology to see how these issues affect brain health in both lab samples and live mice.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10805120 on NIH RePORTER |
What this research studies
This research explores the relationship between mitochondrial dysfunction and tau pathology in Alzheimer's disease (AD), which is a leading cause of dementia. Using innovative optogenetic technology, the study aims to manipulate mitochondrial function and reactive oxygen species (ROS) production in real-time to determine their roles in the progression of tau pathology. By employing light-activated tools, researchers will be able to control these processes in both brain slice cultures and live mouse models, providing insights into the underlying mechanisms of AD. This approach seeks to clarify the complex interactions between these factors and their impact on neuronal health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or are at risk for developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow or halt the progression of Alzheimer's disease.
How similar studies have performed: While the specific optogenetic approach is novel, previous research has shown that targeting mitochondrial function can have beneficial effects in neurodegenerative diseases.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Wojtovich, Andrew Phillip — University of Rochester
- Study coordinator: Wojtovich, Andrew Phillip
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.