Investigating how mitochondrial dysfunction affects pulmonary hypertension
Mitochondrial dysfunction in pulmonary hypertension
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10897828
This study is looking at how problems with tiny energy factories in cells, called mitochondria, might contribute to pulmonary arterial hypertension (PAH), and it's using a rat model to find new ways to help improve treatments for people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10897828 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of mitochondrial dysfunction in pulmonary arterial hypertension (PAH), a serious condition that affects blood vessels in the lungs. The team has developed a rat model that mimics the mitochondrial issues seen in PAH patients, allowing them to explore how these dysfunctions contribute to the disease. By examining the connections between mitochondrial health and PAH, the researchers aim to uncover new therapeutic targets that could lead to better treatments for patients. The study involves both pharmacological and genetic approaches to induce mitochondrial dysfunction and observe its effects on PAH development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension, particularly those with genetic predispositions related to mitochondrial dysfunction.
Not a fit: Patients with pulmonary hypertension not related to mitochondrial dysfunction or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from pulmonary arterial hypertension.
How similar studies have performed: Previous research has indicated a strong link between mitochondrial dysfunction and pulmonary hypertension, suggesting that this approach has the potential for significant breakthroughs.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAFIKOVA, OLGA — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: RAFIKOVA, OLGA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers