Investigating how mitochondrial dysfunction affects atrial fibrillation
Genes and Metabolism: Targeting Mitochondrial Dysfunction in Atrial Fibrillation
This study is looking at how problems with tiny energy factories in heart cells, called mitochondria, might make atrial fibrillation (AF) worse, especially as we age or face stress, and it hopes to find new ways to help keep your heart healthy and manage AF better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10896385 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mitochondrial dysfunction in the progression of atrial fibrillation (AF), a common heart rhythm disorder. By examining how metabolic stressors and aging contribute to mitochondrial damage, the study aims to identify potential interventions that could slow or reverse AF progression. The researchers will utilize engineered heart tissues derived from human stem cells to explore the effects of these stressors on heart cell function. This approach may lead to new treatments that enhance mitochondrial resilience and improve heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for atrial fibrillation due to factors like obesity, hypertension, or metabolic syndrome.
Not a fit: Patients who do not have risk factors for atrial fibrillation or those with advanced heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of atrial fibrillation and its associated complications.
How similar studies have performed: Previous research has shown promising results in targeting mitochondrial dysfunction for various cardiovascular conditions, suggesting potential for success in this area as well.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Van Wagoner, David R — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Van Wagoner, David R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.