Investigating how mitochondrial DNA affects lung inflammation and recovery
The mitochondrial genome in lung disease: a signaling hub linking the persistence and severity of inflammation to recovery
['FUNDING_R01'] · UNIVERSITY OF SOUTH ALABAMA · NIH-11056109
This study is looking at how tiny pieces of DNA from our cells' energy factories, called mitochondria, affect lung diseases by influencing inflammation and healing, with the hope of finding new ways to help people recover from these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH ALABAMA (nih funded) |
| Locations | 1 site (MOBILE, UNITED STATES) |
| Trial ID | NIH-11056109 on ClinicalTrials.gov |
What this research studies
This research explores the role of mitochondrial DNA in lung diseases, particularly how it influences inflammation and recovery processes. By examining the damage caused by reactive oxygen species, the study aims to understand how mitochondrial DNA fragments trigger inflammatory responses and the subsequent healing mechanisms. The research will utilize advanced analytical methods to assess the relationship between mitochondrial function, DNA repair, and inflammation resolution, potentially leading to new therapeutic strategies for lung conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with acute lung injury or other inflammatory lung conditions.
Not a fit: Patients with chronic lung diseases unrelated to inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from inflammatory lung diseases.
How similar studies have performed: Other research has shown promising results in understanding the role of mitochondrial function in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
MOBILE, UNITED STATES
- UNIVERSITY OF SOUTH ALABAMA — MOBILE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GILLESPIE, MARK N — UNIVERSITY OF SOUTH ALABAMA
- Study coordinator: GILLESPIE, MARK N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury