Investigating how mitochondrial DNA affects immune responses in Alzheimer's disease
mtDNA leakage and STING-dependent microglial innate immune response in Alzheimer's disease
['FUNDING_R01'] · UNIVERSITY OF KANSAS LAWRENCE · NIH-10991306
This study is looking at how a part of our cells called mitochondrial DNA affects brain cells involved in inflammation during Alzheimer's disease, and it's for anyone interested in understanding how we might find new ways to help manage this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS LAWRENCE (nih funded) |
| Locations | 1 site (LAWRENCE, UNITED STATES) |
| Trial ID | NIH-10991306 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of mitochondrial DNA (mtDNA) in activating the immune response of microglia, which are brain cells that become inflamed in Alzheimer's disease (AD). The study examines how the STING protein, which is involved in immune signaling, contributes to this inflammatory process when mtDNA accumulates in the brain. By using both patient samples and animal models, the researchers aim to uncover the mechanisms behind microglial activation and its impact on cognitive decline in AD. This could lead to new insights into potential therapeutic targets for managing Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, particularly those experiencing cognitive decline.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation in the brain and slow the progression of Alzheimer's disease.
How similar studies have performed: While the specific approach of targeting STING in Alzheimer's disease is relatively novel, similar research has shown promise in understanding immune responses in other neurodegenerative conditions.
Where this research is happening
LAWRENCE, UNITED STATES
- UNIVERSITY OF KANSAS LAWRENCE — LAWRENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DU, HENG — UNIVERSITY OF KANSAS LAWRENCE
- Study coordinator: DU, HENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury