Investigating how mitochondrial DNA affects immune response after cardiac arrest
The Role of Mitochondrial DNA in Innate Immune Activation after Sudden CardiacArrest
This study is looking at how tiny pieces of DNA from our cells might cause inflammation after a sudden cardiac arrest, especially in veterans, with the hope of finding new ways to help improve recovery and survival.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louis Stokes Cleveland VA Medical Center NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10911024 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mitochondrial DNA in triggering inflammation following sudden cardiac arrest, a condition that significantly impacts survival rates among hospitalized veterans. The study aims to explore how the release of mitochondrial DNA during ischemia-reperfusion injury contributes to cardiac dysfunction and inflammation. By examining the mechanisms involved, including the cGAS/STING signaling pathway, the research seeks to identify potential therapeutic strategies that could improve patient outcomes. The approach includes both in vitro microscopy techniques and in vivo models to validate findings.
Who could benefit from this research
Good fit: Ideal candidates for this research include hospitalized veterans who have experienced sudden cardiac arrest and are at risk of systemic organ damage.
Not a fit: Patients who have not experienced sudden cardiac arrest or those with pre-existing severe cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance survival and recovery for patients who experience sudden cardiac arrest.
How similar studies have performed: While the specific approach of targeting mitochondrial DNA in this context is novel, preliminary studies have shown promise in related areas of cardiac research.
Where this research is happening
Cleveland, United States
- Louis Stokes Cleveland VA Medical Center — Cleveland, United States (Active)
Researchers
- Principal investigator: Rutledge, Cody Andrew — Louis Stokes Cleveland VA Medical Center
- Study coordinator: Rutledge, Cody Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.