Investigating how mitochondrial division affects melanoma and its treatment
Chronic Mitochondrial Division and Melanoma: Mechanism, Prognosis, and Therapy
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11088724
This study is looking at how changes in tiny parts of cells called mitochondria affect melanoma, with the goal of finding new ways to improve treatment for patients by understanding how their cancer cells work.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11088724 on ClinicalTrials.gov |
What this research studies
This research explores the role of mitochondrial dynamics in melanoma, focusing on how chronic mitochondrial division can influence cancer cell metabolism and response to therapy. By examining the mechanisms behind mitochondrial dysfunction in cancer cells, the study aims to identify potential therapeutic targets that could improve treatment outcomes. Patients may benefit from insights into how their cancer cells behave and how therapies can be tailored to counteract these effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with melanoma, particularly those with mutations in the MAPK pathway.
Not a fit: Patients with non-melanoma skin cancers or those without mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for melanoma by targeting mitochondrial dysfunction.
How similar studies have performed: Previous research has shown promising results in targeting mitochondrial dysfunction in various cancers, suggesting that this approach may be effective for melanoma as well.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHIPUK, JERRY EDWARD — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: CHIPUK, JERRY EDWARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, Cancer Biology, cancer cell, cancer cell metabolism, Cancer Genes