Investigating how mitochondrial Complex I deficiency affects Alzheimer's disease and dementia
Role of mitochondrial Complex I deficiency in Alzheimer disease and dementia
This study is looking at how a problem with a part of our cells called mitochondrial Complex I might be linked to Alzheimer's disease and dementia, using specially modified mice to see how this issue affects the buildup of a protein related to Alzheimer's, with the goal of finding new ways to help treat these conditions.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10790090 on NIH RePORTER |
What this research studies
This research explores the connection between mitochondrial Complex I deficiency and the development of Alzheimer's disease (AD) and dementia. The study aims to understand how this deficiency may lead to increased neuroinflammation and protein aggregation, which are key features of AD. Researchers will use genetically modified mice to examine the effects of Complex I deficiency on amyloid beta protein accumulation, a hallmark of Alzheimer's. By identifying these mechanisms, the research hopes to shed light on potential new targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those with a family history or genetic predisposition.
Not a fit: Patients with advanced Alzheimer's disease or those without any genetic risk factors for the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating Alzheimer's disease and dementia.
How similar studies have performed: Previous research has indicated that mitochondrial dysfunction plays a role in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Polster, Brian M — University of Maryland Baltimore
- Study coordinator: Polster, Brian M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.