Investigating how mitochondrial calcium affects Alzheimer's disease progression
Mitochondrial calcium uptake in Alzheimer’s disease
This study is looking at how changes in calcium levels in tiny energy factories in our cells might affect memory loss and brain cell damage in Alzheimer's disease, using special mice to help us understand this better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10913460 on NIH RePORTER |
What this research studies
This research explores the role of mitochondrial calcium uptake in the progression of Alzheimer's disease (AD). By using genetically modified mice, the study aims to understand how changes in mitochondrial calcium levels may contribute to memory loss and neuronal cell death associated with AD. The researchers will assess various factors such as memory function, amyloid plaque formation, and metabolic changes in these mice to determine the impact of mitochondrial calcium on disease development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting mitochondrial calcium regulation to slow or prevent Alzheimer's disease progression.
How similar studies have performed: While the specific approach of targeting mitochondrial calcium uptake in Alzheimer's is relatively novel, similar studies have shown promising results in understanding calcium dysregulation in neurodegenerative diseases.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Jadiya, Pooja — Wake Forest University Health Sciences
- Study coordinator: Jadiya, Pooja
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.