Investigating how mitochondrial antioxidants affect tumor growth in breast cancer
The role of mitochondrial glutathione homeostasis in tumor formation
This study is looking at how a special antioxidant in our cells, called mitochondrial glutathione, affects breast cancer growth and spread, with the hope that understanding this could help develop new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11047568 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mitochondrial glutathione, a key antioxidant, in the development and progression of breast cancer. The study examines how cancer cells utilize mitochondrial antioxidants to manage oxidative stress caused by reactive oxygen species (ROS). By exploring the mechanisms that regulate mitochondrial redox homeostasis, particularly through a protein called SLC25A39, the research aims to uncover how these processes contribute to tumor invasion and metastasis. Patients may benefit from insights that could lead to new therapeutic strategies targeting mitochondrial functions in cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients, particularly those with aggressive forms of the disease or those who have experienced metastasis.
Not a fit: Patients with non-breast cancer types or those whose tumors do not exhibit mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that improve outcomes for breast cancer patients by targeting mitochondrial antioxidant mechanisms.
How similar studies have performed: Previous studies have shown promising results in targeting mitochondrial functions in cancer, suggesting that this approach may yield significant insights and advancements.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Birsoy, Kivanc — Rockefeller University
- Study coordinator: Birsoy, Kivanc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.