Investigating how mitochondria function in lung tumors that resist treatment
In vivo imaging of mitochondria structure and function in therapy resistant lung tumors
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10977423
This study is looking for better ways to help people with non-small cell lung cancer by using a special imaging tool to understand how their tumors work, especially those that don’t respond to regular treatments, so that doctors can create more personalized and effective treatment plans.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10977423 on ClinicalTrials.gov |
What this research studies
This research focuses on improving survival rates for patients with non-small cell lung cancer (NSCLC) by exploring new diagnostic and therapeutic strategies. It aims to use a specific PET tracer, 18F-BnTP, to identify metabolic signatures of lung tumors, particularly those that are resistant to standard therapies. By classifying tumors based on their metabolic dependencies rather than just genetic mutations, the study seeks to develop targeted treatments that address the unique energy needs of these cancer cells. This approach could lead to more effective management of therapy-resistant lung tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer, particularly those with KRAS, LKB1, or EGFR mutations who have not responded to standard therapies.
Not a fit: Patients with early-stage lung cancer or those who have not yet undergone treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new diagnostic tools and treatment options for patients with therapy-resistant lung tumors, potentially improving their survival rates.
How similar studies have performed: Other research has shown promise in using metabolic profiling to guide cancer treatment, indicating that this approach could be effective.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHACKELFORD, DAVID B — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: SHACKELFORD, DAVID B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.