Investigating how mitochondria function in lung tumors that resist treatment
In vivo imaging of mitochondria structure and function in therapy resistant lung tumors
This study is looking for better ways to help people with non-small cell lung cancer by using a special imaging tool to understand how their tumors behave, so doctors can create more personalized treatments for those whose cancer doesn't respond to standard therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10867516 on NIH RePORTER |
What this research studies
This research focuses on improving survival rates for patients with non-small cell lung cancer (NSCLC) by exploring new diagnostic and therapeutic strategies. It aims to use a specific PET tracer, 18F-BnTP, to identify metabolic patterns in lung tumors that are resistant to standard therapies. By classifying tumors based on their metabolic signatures rather than just genetic mutations, the study seeks to develop targeted treatments that address the unique energy needs of these tumors. This approach could lead to more effective management of therapy-resistant lung cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer, particularly those with KRAS, LKB1, or EGFR mutations who have not responded to standard therapies.
Not a fit: Patients with early-stage lung cancer or those who have not undergone prior treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and survival rates for patients with therapy-resistant lung tumors.
How similar studies have performed: Previous research has shown promise in using metabolic profiling to inform treatment strategies in cancer, suggesting that this approach could be effective.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Shackelford, David B — University of California Los Angeles
- Study coordinator: Shackelford, David B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.