Investigating how mitochondria contribute to brain damage after injury
Official title: The cell-specific neurodegenerative potential of mitochondria post-traumatic brain injury
Funded at University of Cincinnati · NIH-10988836 · Data updated 2026-11-12
This study is looking at how a traumatic brain injury can mess with the tiny power plants in our cells, which might lead to problems like Alzheimer's, and it's for anyone interested in understanding how TBI affects the brain and finding better ways to help those who are struggling with its long-term effects.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $158,247 |
| NIH project number | 1R21AG085052-01A1 |
| Project ID | NIH-10988836 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced a traumatic brain injury and are at risk for developing neurodegenerative conditions.
✕Less likely to help
Patients who have not suffered a traumatic brain injury or do not exhibit any neurodegenerative symptoms may not benefit from this research.
What this research studies
This research explores how traumatic brain injury (TBI) affects mitochondria, the energy-producing structures in cells, leading to neurodegenerative changes. It aims to understand the specific ways in which mitochondrial dysfunction can trigger inflammation and neuronal damage, potentially resulting in conditions like Alzheimer's disease. By analyzing human data and conducting preliminary experiments, the researchers hope to uncover the mechanisms behind these processes and identify potential biomarkers for diagnosis and treatment. This work is crucial for developing effective interventions for individuals suffering from the long-term effects of TBI.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and treatments for patients with traumatic brain injuries and related neurodegenerative diseases.
How similar studies have gone: Previous research has indicated that mitochondrial dysfunction plays a significant role in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Liaudanskaya, Volha — University of Cincinnati
- Study coordinator: Liaudanskaya, Volha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.