Investigating how mitochondria and metabolism affect Alzheimer's disease
Mitochondria and metabolism in neurodegeneration
This study is looking at how changes in tiny parts of our cells called mitochondria and their handling of calcium might affect the brain as Alzheimer's disease progresses, using special mouse models to help find new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11077228 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mitochondria and calcium metabolism in the progression of Alzheimer's disease (AD). By using genetically modified mouse models, the study aims to explore how alterations in mitochondrial calcium handling contribute to neuronal dysfunction and cell death associated with AD. The researchers will examine the mechanisms of mitochondrial calcium uptake and efflux, which are believed to be critical in the development of AD pathology. This work could lead to new insights into potential therapeutic targets for treating Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who are at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve neuronal health and slow the progression of Alzheimer's disease.
How similar studies have performed: While the approach of targeting mitochondrial function in Alzheimer's disease is gaining interest, this specific genetic modulation strategy has not been extensively tested in vivo, making it a novel investigation.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Elrod, John William — Temple Univ of the Commonwealth
- Study coordinator: Elrod, John William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.