Investigating how misfolded proteins contribute to multiple sclerosis
Multiple sclerosis as a cytodegenerative proteopathy
This study is looking into how misfolded proteins might be causing multiple sclerosis and how they affect brain health, with the hope of finding new treatments that could help people with MS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Calgary NIH-funded |
| Lab location | 1 site (Calgary, Canada) |
| Project ID | NIH-11005392 on NIH RePORTER |
What this research studies
This research explores the hypothesis that multiple sclerosis (MS) is primarily caused by the misfolding of proteins, leading to damage in the myelin and oligodendrocytes in the central nervous system. The study aims to understand how these misfolded proteins can transmit pathology and provoke an autoimmune response in individuals predisposed to MS. By using advanced imaging techniques and animal models, researchers will examine the effects of these protein aggregates on brain health and function. Patients may benefit from insights that could lead to new treatment strategies targeting the underlying causes of MS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those with progressive forms of the disease.
Not a fit: Patients with other neurological disorders unrelated to protein misfolding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that address the root causes of multiple sclerosis rather than just managing symptoms.
How similar studies have performed: While the concept of protein misfolding in neurological diseases is gaining traction, this specific approach to MS is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
Calgary, Canada
- University of Calgary — Calgary, Canada (Active)
Researchers
- Principal investigator: Stys, Peter K — University of Calgary
- Study coordinator: Stys, Peter K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.