Investigating how misfolded huntingtin protein contributes to Huntington's disease
Genetically Encoded Probes of Huntingtin Misfolding
This study is looking at Huntington's disease and trying to create special tools that can spot early signs of a problem with a protein involved in the disease, which could help us understand how it develops and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10886782 on NIH RePORTER |
What this research studies
This research focuses on Huntington's disease, which is linked to the misfolding of the huntingtin protein. The team aims to develop genetically encoded probes that can detect early misfolded forms of this protein, which are crucial in understanding the disease's progression. By identifying these misfolded species, the researchers hope to explore their potential as biomarkers or therapeutic targets. The approach involves advanced techniques in peptide ligand discovery and protein structure analysis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington's disease or those at risk due to family history.
Not a fit: Patients with other forms of dementia unrelated to Huntington's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and treatments for Huntington's disease.
How similar studies have performed: Previous research has shown promise in targeting misfolded proteins in neurodegenerative diseases, suggesting potential for success in this novel approach.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Langen, Ralf — University of Southern California
- Study coordinator: Langen, Ralf
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.