Investigating how misalignment of the body's internal clock affects heart rhythm problems
Role of cardiac clock misalignment in promoting arrhythmias in swine and donor human hearts
This study is looking at how our body's natural clock affects heart rhythms, especially for people with ongoing heart issues, to see if fixing these rhythms can help prevent dangerous heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-11126217 on NIH RePORTER |
What this research studies
This research explores the connection between the body's circadian rhythms and the occurrence of dangerous heart rhythms, known as arrhythmias, particularly in patients with chronic heart conditions. By using both swine models and donor human hearts, the study aims to identify how disruptions in the body's internal clock can lead to increased risk of sudden cardiac arrest. The researchers will employ advanced mapping techniques to observe heart activity at different times of the day, and they will also test whether adjusting these circadian rhythms can reduce the risk of arrhythmias. This approach could provide new insights into heart health and treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of heart disease or those at risk for sudden cardiac arrest due to arrhythmias.
Not a fit: Patients without any cardiovascular issues or those who do not experience arrhythmias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing life-threatening heart rhythm issues in patients with heart disease.
How similar studies have performed: While the specific approach of aligning circadian rhythms with heart health is relatively novel, there is growing evidence that circadian biology plays a significant role in cardiovascular health.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Aras, Kedar Kirtikumar — State University of New York at Buffalo
- Study coordinator: Aras, Kedar Kirtikumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.