Investigating how miR-301b affects heart cell function in children with heart failure
Official title: miR-301b inhibits autophagy by directly targeting RAB5A
Funded at University of Colorado Denver · NIH-11034986 · Data updated 2026-11-12
This study is looking at a molecule called miR-301b in the hearts of children with dilated cardiomyopathy, a condition that can cause serious heart problems, to see how it affects heart cell health and could help find better treatments for these kids.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $122,387 |
| NIH project number | 1K01HL177545-01 |
| Project ID | NIH-11034986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children over the age of 1 year diagnosed with dilated cardiomyopathy.
✕Less likely to help
Patients with heart failure due to causes other than dilated cardiomyopathy may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific molecule, miR-301b, in the hearts of children suffering from dilated cardiomyopathy (DCM), a condition that can lead to severe heart failure. The study aims to explore how miR-301b influences the process of autophagy, which is crucial for cell health, by examining heart tissue samples from pediatric patients. Additionally, the research will involve laboratory experiments to see how increasing miR-301b levels affects heart cells and their ability to manage waste and survive. By identifying the mechanisms behind heart failure in children, the research seeks to pave the way for more effective treatments tailored to this age group.
Why it matters
Potential benefit: If successful, this research could lead to new, age-specific therapies for children with heart failure, improving their health outcomes.
How similar studies have gone: While research on miR-301b is emerging, this specific investigation into its role in pediatric heart failure is relatively novel.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Hailu, Frehiwet Tesfu — University of Colorado Denver
- Study coordinator: Hailu, Frehiwet Tesfu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.