Investigating how miR-21 affects autoimmune responses in lupus nephritis
miR-21 regulation of autoreactive B cell and lupus nephritis development
['FUNDING_R01'] · THOMAS JEFFERSON UNIVERSITY · NIH-10897117
This study is looking at how a tiny molecule called miR-21 affects the immune system in people with lupus and kidney problems related to it, hoping to find new ways to help those living with this challenging condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10897117 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a specific microRNA, miR-21, in the development of systemic lupus erythematosus (SLE) and lupus nephritis. By studying mouse models, the researchers aim to uncover how miR-21 influences B cell behavior and autoantibody production, which are critical in the progression of autoimmune diseases. The project seeks to identify the mechanisms by which miR-21 contributes to the loss of immune tolerance and the development of SLE, potentially leading to new targeted therapies for patients suffering from this debilitating condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with systemic lupus erythematosus, particularly those experiencing kidney involvement.
Not a fit: Patients with autoimmune conditions other than lupus nephritis may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve treatment outcomes for patients with lupus nephritis.
How similar studies have performed: Previous research has shown promising results in targeting microRNAs for therapeutic purposes in autoimmune diseases, suggesting a potential for success in this approach.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAHMAN, ZIAUR — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: RAHMAN, ZIAUR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.