Investigating how miR-142 affects the progression of blood disorders into acute myeloid leukemia.
The Role of miR-142 in the Transformation of Clonal Hematopoietic Disorders into AML
This study is looking at how a tiny molecule called miR-142 might play a role in turning chronic blood disorders into acute myeloid leukemia (AML), and it's for people with these blood conditions who want to know more about potential new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11002017 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific microRNA, miR-142, in the transformation of chronic blood disorders into acute myeloid leukemia (AML). By studying how miR-142 influences the behavior of hematopoietic stem cells, the research aims to uncover new mechanisms that lead to AML development. The approach involves using animal models to observe the effects of miR-142 deficiency on blood cell production and disease progression. The ultimate goal is to identify potential new treatment strategies for patients with these blood disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with chronic clonal blood disorders, such as myeloproliferative neoplasms or chronic myelogenous leukemia, who are at risk of developing acute myeloid leukemia.
Not a fit: Patients with acute myeloid leukemia who do not have a history of chronic clonal blood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that improve outcomes for patients with acute myeloid leukemia and related conditions.
How similar studies have performed: Other research has shown promising results in targeting microRNAs for therapeutic purposes in hematological malignancies, suggesting that this approach may be viable.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Marcucci, Guido — Beckman Research Institute/city of Hope
- Study coordinator: Marcucci, Guido
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.