Investigating how mild traumatic brain injury affects pain sensitivity and light sensitivity in children.
The trigeminal nociceptive-pain pathway in pediatric mTBI: peripheral and central contributions to photophobia
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-10894836
This study is looking at how mild brain injuries affect kids, especially how it relates to facial sensations and light sensitivity, to help find better ways to diagnose and treat them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10894836 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the effects of mild traumatic brain injury (mTBI) on children, particularly how it impacts the trigeminal nerve, which is responsible for sensations in the face and eyes. The study will utilize advanced techniques such as quantitative sensory testing, corneal nerve microscopy, and brain imaging to explore the relationship between mTBI and symptoms like sensitivity to light (photophobia). By examining both peripheral and central nervous system changes, the research aims to identify potential diagnostic markers and improve treatment strategies for children suffering from head trauma.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 who have experienced a mild traumatic brain injury.
Not a fit: Patients who have not experienced a mild traumatic brain injury or are outside the age range of 0-21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment options for children experiencing pain and light sensitivity after a concussion.
How similar studies have performed: Previous research has shown promising results in understanding the neurological impacts of mTBI, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOULTON, ERIC ALAN — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: MOULTON, ERIC ALAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.