Investigating how microvesicles affect liver disease caused by alcohol
Official title: The role of matrix-bound microvesicles in alcohol-related liver disease
Funded at University of Pittsburgh at Pittsburgh · NIH-11059845 · Data updated 2026-11-12
This study is looking at tiny particles that are linked to liver tissue to see how they affect liver damage from alcohol, with the hope of finding new ways to help people with alcohol-related liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | May 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $483,165 |
| NIH project number | 5R01AA030007-03 |
| Project ID | NIH-11059845 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with alcohol-related liver disease or those experiencing liver injury due to alcohol consumption.
✕Less likely to help
Patients with liver disease not related to alcohol consumption may not benefit from this research.
What this research studies
This research focuses on understanding the role of microvesicles bound to the extracellular matrix in the development and progression of alcohol-related liver disease (ALD). By examining how these microvesicles influence liver damage and fibrosis, the study aims to uncover new therapeutic targets. The approach involves analyzing changes in the extracellular matrix and its components during liver injury caused by alcohol. This could lead to a better understanding of the inflammatory and tissue responses associated with ALD.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients suffering from alcohol-related liver disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of the extracellular matrix in liver diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Scott, Melanie J. — University of Pittsburgh at Pittsburgh
- Study coordinator: Scott, Melanie J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.