Investigating how microtubules function in cells
Single-molecule interrogation of microtubule dynamics mechanisms
This study is looking at how tiny structures in our cells, called microtubules, work and interact, which is important for understanding how cells divide and function, and it could help us learn more about how these structures respond to cancer treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10673855 on NIH RePORTER |
What this research studies
This research focuses on understanding the dynamics of microtubules, which are essential components of eukaryotic cells involved in processes like chromosome segregation and intracellular organization. By using advanced microscopy techniques, the study aims to observe and quantify the interactions of tubulin proteins at the microtubule ends, which are crucial for their assembly and function. The research will compare the behavior of tubulin from yeast and humans to uncover general mechanisms that govern microtubule dynamics. This could lead to insights into how microtubules respond to anti-cancer drugs and their role in cell behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that are treated with microtubule-targeting agents, such as taxol.
Not a fit: Patients with conditions unrelated to microtubule dynamics or those not undergoing treatment with microtubule-targeting drugs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cancers that target microtubules.
How similar studies have performed: Previous research has shown success in using similar microscopy techniques to study protein interactions, indicating a promising approach for this investigation.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Rice, Luke W — Ut Southwestern Medical Center
- Study coordinator: Rice, Luke W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.