Investigating how microtubule networks affect memory loss in Alzheimer's disease
Official title: The role of microtubule network in a mouse model of Alzheimer’s disease
Funded at Rutgers, the State Univ of N.j. · NIH-11144610 · Data updated 2026-11-12
This study is looking at how a protein called tau affects memory loss in Alzheimer's by using mice to see how changes in tiny structures in the brain, called microtubules, might influence memory and could help find new treatments for the disease.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | August 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $148,171 |
| NIH project number | 5R03AG085121-02 |
| Project ID | NIH-11144610 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old who are experiencing symptoms of Alzheimer's disease or related dementias.
✕Less likely to help
Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of microtubule stability and its impact on memory loss in Alzheimer's disease using a mouse model. Researchers will examine how alterations in a protein called tau, which stabilizes microtubules, affect neuronal transport and memory formation. By studying the dynamics of microtubules and their relationship with memory consolidation, the research aims to uncover mechanisms that could lead to new therapeutic strategies for Alzheimer's. The approach involves observing changes in microtubule stability in response to various activities in the brain.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for memory loss associated with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of microtubule dynamics in memory function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Shumyatsky, Gleb P — Rutgers, the State Univ of N.j.
- Study coordinator: Shumyatsky, Gleb P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.