Investigating how microRNAs in extracellular vesicles affect heart disease in people living with HIV
The role of extracellular vesicle-associated MicroRNAs in HIV-associated atherosclerosis
This study is looking at how HIV might raise the risk of heart problems by checking tiny particles called extracellular vesicles that carry important messages between cells, and it's for people living with HIV who want to understand more about their heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11002014 on NIH RePORTER |
What this research studies
This research explores the connection between HIV and an increased risk of cardiovascular diseases by examining extracellular vesicles (EVs) that carry microRNAs. These EVs are released by cells and can influence the behavior of other cells, particularly those in the cardiovascular system. By analyzing the differences in EVs from people living with HIV on antiretroviral therapy, the study aims to understand how these vesicles contribute to heart disease. The research involves injecting different types of EVs into mice to observe their effects on atherosclerosis development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are on antiretroviral therapy and have an undetectable viral load.
Not a fit: Patients who are HIV negative or those not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular diseases in people living with HIV.
How similar studies have performed: Previous research has shown that extracellular vesicles play a significant role in various diseases, suggesting that this approach may yield valuable insights into HIV-related cardiovascular risks.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Dong, Chunming — University of Miami School of Medicine
- Study coordinator: Dong, Chunming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.