Investigating how microRNAs affect epilepsy development
Functional analysis of the microRNA-induced silencing complex in epilepsy
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10745956
This study is looking at how a tiny part of our cells, called RISC, might affect the development of epilepsy after a big seizure, with the hope of finding new ways to help people who have trouble with their seizures, especially those who don’t respond to current treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10745956 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the microRNA-induced silencing complex (RISC) in the development of epilepsy, particularly after a seizure event known as status epilepticus. By analyzing how RISC regulates gene expression, the study aims to uncover the complex molecular mechanisms that lead to spontaneous recurrent seizures. The approach involves manipulating various molecular pathways to identify potential new treatment strategies that could prevent or reduce the onset of epilepsy. Patients may benefit from insights gained that could lead to more effective therapies for drug-resistant epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with drug-resistant epilepsy or those who have experienced status epilepticus.
Not a fit: Patients with epilepsy that is well-controlled by existing medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments that effectively prevent or reduce seizures in patients with epilepsy.
How similar studies have performed: Previous research has shown promising results in manipulating microRNAs to reduce seizure susceptibility in animal models, indicating potential for success in this area.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GROSS, CHRISTINA — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: GROSS, CHRISTINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.