Investigating how microRNAs affect airway smooth muscle function in asthma
MicroRNAs in Airway Smooth Muscle Function and Asthma
This study is looking at tiny molecules called microRNAs to see how they affect the muscles in the airways of children with asthma, with the hope of finding new ways to help treat asthma symptoms better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11039406 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of microRNAs in the function of airway smooth muscle (ASM) and their impact on asthma, particularly in children. The study aims to identify specific microRNAs that regulate ASM characteristics such as proliferation and contractility, which are crucial in the development of asthma symptoms. By using advanced techniques like CRISPR and microRNA mimics, researchers will explore how these molecular regulators contribute to airway hyperresponsiveness and asthma severity. The ultimate goal is to uncover new therapeutic targets that could lead to more effective asthma treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have been diagnosed with asthma or exhibit symptoms of airway hyperresponsiveness.
Not a fit: Patients who do not have asthma or related airway conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that better manage asthma symptoms and improve the quality of life for patients.
How similar studies have performed: Previous research has shown promise in targeting microRNAs for therapeutic purposes in various conditions, suggesting potential success for this approach in asthma.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Lu, Quan — Harvard School of Public Health
- Study coordinator: Lu, Quan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.