Investigating how microRNA affects iron and proteins related to Alzheimer's disease
Role of microRNA in regulating Fe, Amyloid, and Tau (FeAT) in Alzheimer's disease
This study is looking at tiny molecules called microRNAs to see how they affect iron levels and important proteins in the brain related to Alzheimer's disease, with the hope of finding new ways to help prevent or treat the condition for those living with it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10460800 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of microRNAs in Alzheimer's disease, particularly how they influence iron metabolism and the proteins amyloid and tau, which are critical in neurodegeneration. The researchers aim to manipulate specific microRNAs to see if they can redirect iron metabolism and potentially prevent or treat Alzheimer's disease. By studying the interactions between these microRNAs and the genes involved in Alzheimer's, the team hopes to uncover new neurobiological mechanisms that contribute to the disease. This could lead to innovative therapeutic strategies for patients suffering from Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or even prevent Alzheimer's disease.
How similar studies have performed: While the specific approach of manipulating microRNAs in this context is relatively novel, there have been successful studies exploring the role of microRNAs in other neurodegenerative diseases.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Lahiri, Debomoy K — Indiana University Indianapolis
- Study coordinator: Lahiri, Debomoy K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.