Investigating how microRNA-483 affects pancreatic beta-cell function and identity
Official title: microRNA-483 regulation of pancreatic beta-cell function and identity
Funded at Michigan Technological University · NIH-10580237 · Data updated 2026-11-12
This study is looking at how a tiny molecule called microRNA-483 helps keep the insulin-producing cells in your pancreas healthy, and it aims to find out what happens when this molecule is missing, which could help us discover new ways to manage type 2 diabetes.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan Technological University NIH-funded |
| Lab location | 1 site (Houghton, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $404,303 |
| NIH project number | 1R15DK134992-01 |
| Project ID | NIH-10580237 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes, particularly those experiencing challenges related to beta-cell function.
✕Less likely to help
Patients with type 1 diabetes or those without any form of diabetes may not benefit from this research.
What this research studies
This research focuses on understanding the role of microRNA-483 in maintaining the function and identity of pancreatic beta-cells, which are crucial for insulin production. The study aims to uncover how the loss of this microRNA leads to beta-cell dedifferentiation, a process that contributes to the progression of type 2 diabetes. By using animal models, researchers will analyze the effects of miR-483 deletion on beta-cell health and function, particularly in relation to oxidative stress and cellular viability. The findings could provide insights into new therapeutic targets for diabetes management.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving beta-cell function in patients with type 2 diabetes.
How similar studies have gone: Previous research has shown that targeting microRNAs can influence cellular processes in diabetes, suggesting potential for success in this approach.
Where this research is happening
-
Michigan Technological University
Houghton, United States Active
Researchers
- Principal investigator: Tang, Xiaoqing — Michigan Technological University
- Study coordinator: Tang, Xiaoqing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.