Investigating how microRNA 374 affects chronic pain
Official title: MicroRNA 374 as an Epigenetic Regulator of Chronic Pain
Funded at Duke University · NIH-10975853 · Data updated 2026-11-12
This study is looking at how a tiny molecule called microRNA 374 affects chronic pain conditions like fibromyalgia and jaw pain, and it’s inviting patients to share their experiences and samples to help find new ways to treat these types of pain.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $44,083 |
| NIH project number | 5F31NS130861-02 |
| Project ID | NIH-10975853 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals suffering from chronic primary pain conditions, particularly fibromyalgia or temporomandibular disorder.
✕Less likely to help
Patients with acute pain conditions or those not experiencing chronic pain may not benefit from this research.
What this research studies
This research focuses on understanding the role of microRNA 374 in chronic primary pain conditions like fibromyalgia and temporomandibular disorder. It examines how genetic and environmental factors influence pain through catecholamine signaling and the regulation of microRNAs. By studying patients and animal models, the research aims to uncover the mechanisms by which microRNA dysregulation contributes to pain, potentially leading to new therapeutic targets. Patients with chronic pain conditions may provide samples and data to help elucidate these relationships.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic pain conditions that are more effective and targeted.
How similar studies have gone: Previous research has shown promising results in understanding the role of microRNAs in pain regulation, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Hernandez, Nathaniel — Duke University
- Study coordinator: Hernandez, Nathaniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.