Investigating how microglial SYK signaling affects Alzheimer's disease and related disorders
Exploring the Role of Microglia SYK Signaling in Tauopathy
This study is looking at how certain immune signals in brain cells called microglia might affect the progression of Alzheimer's disease and frontotemporal dementia, with the hope that understanding these signals could lead to new treatments to help improve brain health and thinking skills.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10995481 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of microglial SYK signaling in tauopathies, particularly Alzheimer's disease and frontotemporal dementia. It aims to explore how specific immune receptors on microglia influence disease progression and cognitive function. By using mouse models, the study will examine the effects of genetic modifications on microglial SYK and its impact on tau pathology and cognitive outcomes. Patients may benefit from insights that could lead to new therapeutic strategies targeting microglial functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or frontotemporal dementia.
Not a fit: Patients with other forms of dementia not related to tauopathies may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that improve cognitive function and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting microglial receptors in neurodegenerative diseases, indicating potential for success in this approach.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Johnson, Alexis Marie — University of Virginia
- Study coordinator: Johnson, Alexis Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.