Investigating how microglia protect the brain in Alzheimer's disease
Neuroprotective signaling and transcriptional pathways in microglia associated with Alzheimer's disease
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10980548
This study is looking at how certain genes linked to Alzheimer's disease affect brain immune cells called microglia, with the hope of finding ways to boost their protective abilities and help prevent or slow down the disease for those at risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10980548 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of microglia, a type of immune cell in the brain, in Alzheimer's disease. It explores how specific genetic variants associated with Alzheimer's risk affect the function of these cells, particularly their ability to protect against neurodegeneration. By studying the signaling pathways and transcriptional changes in microglia, the research aims to identify potential therapeutic targets that could help prevent or delay the onset of Alzheimer's disease. Patients may benefit from insights gained into how to enhance the protective functions of microglia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, including those with genetic predispositions or early signs of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without any genetic risk factors for the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the brain's natural defenses against Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in understanding microglial function and its implications for Alzheimer's disease, suggesting that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOATE, ALISON M — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: GOATE, ALISON M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome