Investigating how microglia contribute to synapse loss in Alzheimer's disease
Synaptic selectivity for microglial-mediated damage in Alzheimer's Disease
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11051869
This study is looking at how certain immune cells in the brain, called microglia, contribute to the loss of connections between brain cells in Alzheimer's disease, with the hope of finding new ways to help prevent memory loss for people living with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11051869 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of microglia, a type of immune cell in the brain, in the loss of synapses associated with Alzheimer's disease. It aims to uncover how these cells interact with misfolded proteins like Amyloid beta and Tau, which are known to disrupt neuronal function. By studying the mechanisms that lead to synaptic damage, the research seeks to identify specific signals that trigger microglial activity and synapse removal. This could provide insights into potential therapeutic targets for preventing cognitive decline in Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving synaptic function and slowing the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STRITTMATTER, STEPHEN M — YALE UNIVERSITY
- Study coordinator: STRITTMATTER, STEPHEN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia